Whole Genome Analysis of Ovarian Granulosa Cell Tumors Reveals Tumor Heterogeneity and a High-Grade TP53-Specific Subgroup

Adult granulosa cell tumors (AGCTs) harbor a somatic FOXL2 c.402C>G mutation in ~95% of cases and are mainly surgically removed due to limited systemic treatment effect. In this study, potentially targetable genomic alterations in AGCTs were investigated by whole genome sequencing on 46 tumor sam...

Descripción completa

Detalles Bibliográficos
Autores principales: Roze, Joline, Monroe, Glen, Kutzera, Joachim, Groeneweg, Jolijn, Stelloo, Ellen, Paijens, Sterre, Nijman, Hans, van Meurs, Hannah, van Lonkhuijzen, Luc, Piek, Jurgen, Lok, Christianne, Jonges, Geertruida, Witteveen, Petronella, Verheijen, René, van Haaften, Gijs, Zweemer, Ronald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281495/
https://www.ncbi.nlm.nih.gov/pubmed/32455687
http://dx.doi.org/10.3390/cancers12051308

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281495/
https://www.ncbi.nlm.nih.gov/pubmed/32455687
http://dx.doi.org/10.3390/cancers12051308

Ejemplares similares