Cargando…

Whole Genome Analysis of Ovarian Granulosa Cell Tumors Reveals Tumor Heterogeneity and a High-Grade TP53-Specific Subgroup

Adult granulosa cell tumors (AGCTs) harbor a somatic FOXL2 c.402C>G mutation in ~95% of cases and are mainly surgically removed due to limited systemic treatment effect. In this study, potentially targetable genomic alterations in AGCTs were investigated by whole genome sequencing on 46 tumor sam...

Descripción completa

Detalles Bibliográficos
Autores principales:	Roze, Joline, Monroe, Glen, Kutzera, Joachim, Groeneweg, Jolijn, Stelloo, Ellen, Paijens, Sterre, Nijman, Hans, van Meurs, Hannah, van Lonkhuijzen, Luc, Piek, Jurgen, Lok, Christianne, Jonges, Geertruida, Witteveen, Petronella, Verheijen, René, van Haaften, Gijs, Zweemer, Ronald
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281495/ https://www.ncbi.nlm.nih.gov/pubmed/32455687 http://dx.doi.org/10.3390/cancers12051308

Ejemplares similares

In Vitro Systematic Drug Testing Reveals Carboplatin, Paclitaxel, and Alpelisib as a Potential Novel Combination Treatment for Adult Granulosa Cell Tumors
por: Roze, Joline, et al.
Publicado: (2021)

[(18)F]FDG and [(18)F]FES positron emission tomography for disease monitoring and assessment of anti-hormonal treatment eligibility in granulosa cell tumors of the ovary
por: Roze, Joline F., et al.
Publicado: (2021)

Familial Occurrence of Adult Granulosa Cell Tumors: Analysis of Whole-Genome Germline Variants
por: Roze, Joline F., et al.
Publicado: (2021)

Response to Systemic Therapies in Ovarian Adult Granulosa Cell Tumors: A Literature Review
por: Brink, Geertruid J., et al.
Publicado: (2022)

Robot-assisted laparoscopic debulking surgery for recurrent adult granulosa cell tumors
por: Groeneweg, Jolijn W., et al.
Publicado: (2021)

Distinct Genomic Profiles Are Associated with Treatment Response and Survival in Ovarian Cancer
por: de Witte, Chris J., et al.
Publicado: (2022)

Notch signaling in serous ovarian cancer
por: Groeneweg, Jolijn W, et al.
Publicado: (2014)

Clinical and Radiologic Signs of Relapsed Ovarian Germ Cell Tumor: Tissue Is the Issue
por: Homs, M. Y. V., et al.
Publicado: (2013)

Microsatellite instability derived JAK1 frameshift mutations are associated with tumor immune evasion in endometrioid endometrial cancer
por: Stelloo, Ellen, et al.
Publicado: (2016)

Genomic and transcriptomic plasticity in treatment-naïve ovarian cancer
por: Hoogstraat, Marlous, et al.
Publicado: (2014)

Deep immune profiling of ovarian tumors identifies minimal MHC-I expression after neoadjuvant chemotherapy as negatively associated with T-cell-dependent outcome
por: Brunekreeft, Kim L., et al.
Publicado: (2020)

Inhibition of Notch Signaling in Combination with Paclitaxel Reduces Platinum-Resistant Ovarian Tumor Growth
por: Groeneweg, Jolijn W., et al.
Publicado: (2014)

Indocyanine green versus technetium‐99m with blue dye for sentinel lymph node detection in early‐stage cervical cancer: A systematic review and meta‐analysis
por: Baeten, Ilse G. T., et al.
Publicado: (2021)

Fluorescent Indocyanine Green versus Technetium-99m and Blue Dye for Bilateral SENTinel Lymph Node Detection in Stage I–IIA Cervical Cancer (FluoreSENT): protocol for a non-inferiority study
por: Baeten, Ilse G T, et al.
Publicado: (2022)

Expression of CD39 Identifies Activated Intratumoral CD8+ T Cells in Mismatch Repair Deficient Endometrial Cancer
por: Lubbers, Joyce M., et al.
Publicado: (2022)

Hypoxia-Inducible Factor-1 as a Therapeutic Target in Endometrial Cancer Management
por: Seeber, Laura M. S., et al.
Publicado: (2010)

Gastric cancer during pregnancy: A report on 13 cases and review of the literature with focus on chemotherapy during pregnancy
por: Maggen, Charlotte, et al.
Publicado: (2019)

A versatile microsatellite instability reporter system in human cells
por: Koole, Wouter, et al.
Publicado: (2013)

Immunologic aspect of ovarian cancer and p53 as tumor antigen
por: Nijman, HW, et al.
Publicado: (2005)

Increasing experience in laparoscopic staging of early ovarian cancer
por: Schreuder, Henk W. R., et al.
Publicado: (2011)

Whole slide images for primary diagnostics of urinary system pathology: a feasibility study
por: Al-Janabi, Shaimaa, et al.
Publicado: (2014)

From open radical hysterectomy to robot-assisted laparoscopic radical hysterectomy for early stage cervical cancer: aspects of a single institution learning curve
por: Schreuder, H. W. R., et al.
Publicado: (2010)

The progression-free survival ratio as outcome measure in recurrent ovarian carcinoma patients: Current and future perspectives
por: van de Kruis, Nienke, et al.
Publicado: (2022)

Genetic Variants and Anterior Cruciate Ligament Rupture: A Systematic Review
por: Kaynak, Mustafa, et al.
Publicado: (2017)

From Tumor Immunosuppression to Eradication: Targeting Homing and Activity of Immune Effector Cells to Tumors
por: Draghiciu, Oana, et al.
Publicado: (2011)

The influence of learning curve of robot‐assisted laparoscopy on oncological outcomes in early‐stage cervical cancer: an observational cohort study
por: Baeten, IGT, et al.
Publicado: (2020)

The effect of personal medical history and family history of cancer on the uptake of risk-reducing salpingo-oophorectomy
por: van der Aa, Jessica E., et al.
Publicado: (2015)

Empowering pregnant women to improve diet quality: a RCT among pregnant women in the Netherlands
por: van Lonkhuijzen, RM, et al.
Publicado: (2022)

Optimized ChIP-seq method facilitates transcription factor profiling in human tumors
por: Singh, Abhishek A, et al.
Publicado: (2018)

Antiangiogenic tyrosine kinase inhibition related gastrointestinal perforations: a case report and literature review
por: Walraven, Maudy, et al.
Publicado: (2010)

E2F mediates enhanced alternative polyadenylation in proliferation
por: Elkon, Ran, et al.
Publicado: (2012)

Type 2 Diabetes Mellitus and Clinicopathological Tumor Characteristics in Women Diagnosed with Breast Cancer: A Systematic Review and Meta-Analysis
por: Zhang, Fan, et al.
Publicado: (2021)

The decisive role of molecular pathology in presumed somatic metastases of type II testicular germ cell tumors: report of 2 cases
por: Kranendonk, Mariëtte E. G., et al.
Publicado: (2020)

First-in-Human Phase I Clinical Trial of an SFV-Based RNA Replicon Cancer Vaccine against HPV-Induced Cancers
por: Komdeur, Fenne L., et al.
Publicado: (2021)

Glibenclamide and HMR1098 normalize Cantú syndrome‐associated gain‐of‐function currents
por: Houtman, Marien J. C., et al.
Publicado: (2019)

Three‐dimensional facial morphology in Cantú syndrome
por: Roessler, Helen I., et al.
Publicado: (2020)

PB1706: ABL-CLASS GENOMIC BREAKPOINT Q-PCR FOR RELIABLE MEASURABLE RESIDUAL DISEASE MONITORING IN ALL PATIENTS
por: van Outersterp, Inge, et al.
Publicado: (2023)

Endotracheal intubation skills of pediatricians versus anesthetists in neonates and children
por: van Sambeeck, Sam J., et al.
Publicado: (2019)

Tumor Eradication by Wild-type p53-specific Cytotoxic T Lymphocytes
por: Vierboom, Michel P.M., et al.
Publicado: (1997)

No Value for Routine Chest Radiography in the Work-Up of Early Stage Cervical Cancer Patients
por: Hoogendam, Jacob P., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_uclhmvdhcrlr5fo6u1lor29o8j