Tetraploidization of Immortalized Myoblasts Induced by Cell Fusion Drives Myogenic Sarcoma Development with DMD Deletion

Whole-genome doubling is the second most frequent genomic event, after TP53 alterations, in advanced solid tumors and is associated with poor prognosis. Tetraploidization step will lead to aneuploidy and chromosomic rearrangements. The mechanism leading to tetraploid cells is important since endorep...

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Detalles Bibliográficos
Autores principales: Merle, Candice, Thébault, Noémie, LeGuellec, Sophie, Baud, Jessica, Pérot, Gaëlle, Lesluyes, Tom, Delespaul, Lucile, Lartigue, Lydia, Chibon, Frédéric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281535/
https://www.ncbi.nlm.nih.gov/pubmed/32438562
http://dx.doi.org/10.3390/cancers12051281

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281535/
https://www.ncbi.nlm.nih.gov/pubmed/32438562
http://dx.doi.org/10.3390/cancers12051281

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