GRK2-Dependent HuR Phosphorylation Regulates HIF1α Activation under Hypoxia or Adrenergic Stress

Adaptation to hypoxia is a common feature in solid tumors orchestrated by oxygen-dependent and independent upregulation of the hypoxia-inducible factor-1α (HIF-1α). We unveiled that G protein-coupled receptor kinase (GRK2), known to be overexpressed in certain tumors, fosters this hypoxic pathway vi...

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Detalles Bibliográficos
Autores principales: Reglero, Clara, Lafarga, Vanesa, Rivas, Verónica, Albitre, Ángela, Ramos, Paula, Berciano, Susana R., Tapia, Olga, Martínez-Chantar, María L., Mayor Jr, Federico, Penela, Petronila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281538/
https://www.ncbi.nlm.nih.gov/pubmed/32413989
http://dx.doi.org/10.3390/cancers12051216

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281538/
https://www.ncbi.nlm.nih.gov/pubmed/32413989
http://dx.doi.org/10.3390/cancers12051216

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