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GRK2-Dependent HuR Phosphorylation Regulates HIF1α Activation under Hypoxia or Adrenergic Stress

Adaptation to hypoxia is a common feature in solid tumors orchestrated by oxygen-dependent and independent upregulation of the hypoxia-inducible factor-1α (HIF-1α). We unveiled that G protein-coupled receptor kinase (GRK2), known to be overexpressed in certain tumors, fosters this hypoxic pathway vi...

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Detalles Bibliográficos
Autores principales:	Reglero, Clara, Lafarga, Vanesa, Rivas, Verónica, Albitre, Ángela, Ramos, Paula, Berciano, Susana R., Tapia, Olga, Martínez-Chantar, María L., Mayor Jr, Federico, Penela, Petronila
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281538/ https://www.ncbi.nlm.nih.gov/pubmed/32413989 http://dx.doi.org/10.3390/cancers12051216

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