Targeting Nuclear NAD(+) Synthesis Inhibits DNA Repair, Impairs Metabolic Adaptation and Increases Chemosensitivity of U-2OS Osteosarcoma Cells

Osteosarcoma (OS) is the most common bone tumor in children and adolescents. Modern OS treatment, based on the combination of neoadjuvant chemotherapy (cisplatin + doxorubicin + methotrexate) with subsequent surgical removal of the primary tumor and metastases, has dramatically improved overall surv...

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Detalles Bibliográficos
Autores principales: Kiss, Alexandra, Ráduly, Arnold Péter, Regdon, Zsolt, Polgár, Zsuzsanna, Tarapcsák, Szabolcs, Sturniolo, Isotta, El-Hamoly, Tarek, Virág, László, Hegedűs, Csaba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281559/
https://www.ncbi.nlm.nih.gov/pubmed/32392755
http://dx.doi.org/10.3390/cancers12051180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281559/
https://www.ncbi.nlm.nih.gov/pubmed/32392755
http://dx.doi.org/10.3390/cancers12051180

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