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Whole-genome sequencing of glioblastoma reveals enrichment of non-coding constraint mutations in known and novel genes
BACKGROUND: Glioblastoma (GBM) has one of the worst 5-year survival rates of all cancers. While genomic studies of the disease have been performed, alterations in the non-coding regulatory regions of GBM have largely remained unexplored. We apply whole-genome sequencing (WGS) to identify non-coding...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281935/ https://www.ncbi.nlm.nih.gov/pubmed/32513296 http://dx.doi.org/10.1186/s13059-020-02035-x |