Silica nanoparticles induce lung inflammation in mice via ROS/PARP/TRPM2 signaling-mediated lysosome impairment and autophagy dysfunction

BACKGROUND: Wide applications of nanoparticles (NPs) have raised increasing concerns about safety to humans. Oxidative stress and inflammation are extensively investigated as mechanisms for NPs-induced toxicity. Autophagy and lysosomal dysfunction are emerging molecular mechanisms. Inhalation is one...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Mingxiang, Li, Jin, Dong, Shunni, Cai, Xiaobo, Simaiti, Aili, Yang, Xin, Zhu, Xinqiang, Luo, Jianhong, Jiang, Lin-Hua, Du, Binyang, Yu, Peilin, Yang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281956/
https://www.ncbi.nlm.nih.gov/pubmed/32513195
http://dx.doi.org/10.1186/s12989-020-00353-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281956/
https://www.ncbi.nlm.nih.gov/pubmed/32513195
http://dx.doi.org/10.1186/s12989-020-00353-3

Ejemplares similares