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Silica nanoparticles induce lung inflammation in mice via ROS/PARP/TRPM2 signaling-mediated lysosome impairment and autophagy dysfunction

BACKGROUND: Wide applications of nanoparticles (NPs) have raised increasing concerns about safety to humans. Oxidative stress and inflammation are extensively investigated as mechanisms for NPs-induced toxicity. Autophagy and lysosomal dysfunction are emerging molecular mechanisms. Inhalation is one...

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Detalles Bibliográficos
Autores principales:	Wang, Mingxiang, Li, Jin, Dong, Shunni, Cai, Xiaobo, Simaiti, Aili, Yang, Xin, Zhu, Xinqiang, Luo, Jianhong, Jiang, Lin-Hua, Du, Binyang, Yu, Peilin, Yang, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281956/ https://www.ncbi.nlm.nih.gov/pubmed/32513195 http://dx.doi.org/10.1186/s12989-020-00353-3

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