Modulation of dopamine D(1) receptors via histamine H(3) receptors is a novel therapeutic target for Huntington's disease

Early Huntington’s disease (HD) include over-activation of dopamine D(1) receptors (D(1)R), producing an imbalance in dopaminergic neurotransmission and cell death. To reduce D(1)R over-activation, we present a strategy based on targeting complexes of D(1)R and histamine H(3) receptors (H(3)R). Usin...

Descripción completa

Detalles Bibliográficos
Autores principales: Moreno-Delgado, David, Puigdellívol, Mar, Moreno, Estefanía, Rodríguez-Ruiz, Mar, Botta, Joaquín, Gasperini, Paola, Chiarlone, Anna, Howell, Lesley A, Scarselli, Marco, Casadó, Vicent, Cortés, Antoni, Ferré, Sergi, Guzmán, Manuel, Lluís, Carmen, Alberch, Jordi, Canela, Enric I, Ginés, Silvia, McCormick, Peter J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282811/
https://www.ncbi.nlm.nih.gov/pubmed/32513388
http://dx.doi.org/10.7554/eLife.51093

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282811/
https://www.ncbi.nlm.nih.gov/pubmed/32513388
http://dx.doi.org/10.7554/eLife.51093

Ejemplares similares