Intracellular calcium leak lowers glucose storage in human muscle, promoting hyperglycemia and diabetes

Most glucose is processed in muscle, for energy or glycogen stores. Malignant Hyperthermia Susceptibility (MHS) exemplifies muscle conditions that increase [Ca(2+)](cytosol). 42% of MHS patients have hyperglycemia. We show that phosphorylated glycogen phosphorylase (GPa), glycogen synthase (GSa) – r...

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Detalles Bibliográficos
Autores principales: Tammineni, Eshwar R, Kraeva, Natalia, Figueroa, Lourdes, Manno, Carlo, Ibarra, Carlos A, Klip, Amira, Riazi, Sheila, Rios, Eduardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Human Biology and Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282812/
https://www.ncbi.nlm.nih.gov/pubmed/32364497
http://dx.doi.org/10.7554/eLife.53999

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282812/
https://www.ncbi.nlm.nih.gov/pubmed/32364497
http://dx.doi.org/10.7554/eLife.53999

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