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Intracellular calcium leak lowers glucose storage in human muscle, promoting hyperglycemia and diabetes
Most glucose is processed in muscle, for energy or glycogen stores. Malignant Hyperthermia Susceptibility (MHS) exemplifies muscle conditions that increase [Ca(2+)](cytosol). 42% of MHS patients have hyperglycemia. We show that phosphorylated glycogen phosphorylase (GPa), glycogen synthase (GSa) – r...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282812/ https://www.ncbi.nlm.nih.gov/pubmed/32364497 http://dx.doi.org/10.7554/eLife.53999 |