mRNA stem-loops can pause the ribosome by hindering A-site tRNA binding

Although the elongating ribosome is an efficient helicase, certain mRNA stem-loop structures are known to impede ribosome movement along mRNA and stimulate programmed ribosome frameshifting via mechanisms that are not well understood. Using biochemical and single-molecule Förster resonance energy tr...

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Detalles Bibliográficos
Autores principales: Bao, Chen, Loerch, Sarah, Ling, Clarence, Korostelev, Andrei A, Grigorieff, Nikolaus, Ermolenko, Dmitri N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282821/
https://www.ncbi.nlm.nih.gov/pubmed/32427100
http://dx.doi.org/10.7554/eLife.55799

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282821/
https://www.ncbi.nlm.nih.gov/pubmed/32427100
http://dx.doi.org/10.7554/eLife.55799

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