DDB1 E3 ligase controls dietary fructose-induced ChREBPα stabilization and liver steatosis via CRY1

Fructose over-consumption contributes to the development of liver steatosis in part by stimulating ChREBPα-driven de novo lipogenesis. However, the mechanisms by which fructose activates ChREBP pathway remain largely undefined. Here we performed affinity purification of ChREBPα followed by mass spec...

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Detalles Bibliográficos
Autores principales: Tong, Xin, Zhang, Deqiang, Shabandri, Omar, Oh, Joon, Jin, Ethan, Stamper, Kenneth, Yang, Meichan, Zhao, Zifeng, Yin, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282961/
https://www.ncbi.nlm.nih.gov/pubmed/32246987
http://dx.doi.org/10.1016/j.metabol.2020.154222

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282961/
https://www.ncbi.nlm.nih.gov/pubmed/32246987
http://dx.doi.org/10.1016/j.metabol.2020.154222

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