Identifying the role of PrimPol in TDF-induced toxicity and implications of its loss of function mutation in an HIV+ patient

A key component of antiretroviral therapy (ART) for HIV patients is the nucleoside reverse transcriptase inhibitor (NRTI) is tenofovir. Recent reports of tenofovir toxicity in patients taking ART for HIV cannot be explained solely on the basis of off-target inhibition of mitochondrial DNA polymerase...

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Detalles Bibliográficos
Autores principales: Duong, Vincent N., Zhou, Lei, Martínez-Jiménez, María I., He, Linh, Cosme, Moises, Blanco, Luis, Paintsil, Elijah, Anderson, Karen S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283272/
https://www.ncbi.nlm.nih.gov/pubmed/32518272
http://dx.doi.org/10.1038/s41598-020-66153-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283272/
https://www.ncbi.nlm.nih.gov/pubmed/32518272
http://dx.doi.org/10.1038/s41598-020-66153-z

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