Aggrecanase-selective tissue inhibitor of metalloproteinase-3 (TIMP3) protects articular cartilage in a surgical mouse model of osteoarthritis

A key feature of osteoarthritis is the gradual loss of articular cartilage and bone deformation, resulting in the impairment of joint function. The primary cause of cartilage destruction is considered to be the presence of elevated proteases, such as matrix metalloproteinases (MMPs) and a disintegri...

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Detalles Bibliográficos
Autores principales: Nakamura, Hiroyuki, Vo, Phoung, Kanakis, Ioannis, Liu, Ke, Bou-Gharios, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283274/
https://www.ncbi.nlm.nih.gov/pubmed/32518385
http://dx.doi.org/10.1038/s41598-020-66233-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283274/
https://www.ncbi.nlm.nih.gov/pubmed/32518385
http://dx.doi.org/10.1038/s41598-020-66233-0

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