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Donor bone-marrow CXCR4+ Foxp3+ T-regulatory cells are essential for costimulation blockade-induced long-term survival of murine limb transplants

Vascularized composite allotransplantation (VCA) allows tissue replacement after devastating loss but is currently limited in application and may be more widely performed if maintenance immunosuppression was not essential for graft acceptance. We tested whether peri-transplant costimulation blockade...

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Detalles Bibliográficos
Autores principales: Wang, Liqing, Wang, Zhonglin, Han, Rongxiang, Samanta, Arabinda, Ge, Guanghui, Levin, L. Scott, Levine, Matthew H., Hancock, Wayne W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283338/
https://www.ncbi.nlm.nih.gov/pubmed/32518311
http://dx.doi.org/10.1038/s41598-020-66139-x