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Modeling of Mechanosensing Mechanisms Reveals Distinct Cell Migration Modes to Emerge From Combinations of Substrate Stiffness and Adhesion Receptor–Ligand Affinity

Mesenchymal cell migration is an integral process in development and healing. The process is regulated by both mechanical and biochemical properties. Mechanical properties of the environment are sensed through mechanosensing, which consists of molecular responses mediated by mechanical signals. We d...

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Detalles Bibliográficos
Autores principales: Vargas, Diego A., Gonçalves, Inês G., Heck, Tommy, Smeets, Bart, Lafuente-Gracia, Laura, Ramon, Herman, Van Oosterwyck, Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283468/
https://www.ncbi.nlm.nih.gov/pubmed/32582650
http://dx.doi.org/10.3389/fbioe.2020.00459