Structural basis for oligoclonal T cell recognition of a shared p53 cancer neoantigen

Adoptive cell therapy (ACT) with tumor-specific T cells can mediate cancer regression. The main target of tumor-specific T cells are neoantigens arising from mutations in self-proteins. Although the majority of cancer neoantigens are unique to each patient, and therefore not broadly useful for ACT,...

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Detalles Bibliográficos
Autores principales: Wu, Daichao, Gallagher, D. Travis, Gowthaman, Ragul, Pierce, Brian G., Mariuzza, Roy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283474/
https://www.ncbi.nlm.nih.gov/pubmed/32518267
http://dx.doi.org/10.1038/s41467-020-16755-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283474/
https://www.ncbi.nlm.nih.gov/pubmed/32518267
http://dx.doi.org/10.1038/s41467-020-16755-y

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