Alternative macrophage polarisation associated with resistance to anti-PD1 blockade is possibly supported by the splicing of FKBP51 immunophilin in melanoma patients

BACKGROUND: FKBP51 immunophilin is abundantly expressed by immune cells. Co-inhibitory immune receptor signalling generates the splicing isoform FKBP51s. Tregs stained by FKBP51s are increased in melanoma patients and their counts are associated with anti-CTLA-4 response. An expansion of FKBP51s(+)P...

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Detalles Bibliográficos
Autores principales: Troiani, Teresa, Giunta, Emilio Francesco, Tufano, Martina, Vigorito, Vincenza, Arrigo, Paolo D’, Argenziano, Giuseppe, Ciardiello, Fortunato, Romano, Maria Fiammetta, Romano, Simona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283486/
https://www.ncbi.nlm.nih.gov/pubmed/32317723
http://dx.doi.org/10.1038/s41416-020-0840-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283486/
https://www.ncbi.nlm.nih.gov/pubmed/32317723
http://dx.doi.org/10.1038/s41416-020-0840-8

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