Hypertrophic and Dilated Cardiomyopathy-Associated Troponin T Mutations R130C and ΔK210 Oppositely Affect Length-Dependent Calcium Sensitivity of Force Generation

Length-dependent activation of calcium-dependent myocardial force generation provides the basis for the Frank-Starling mechanism. To directly compare the effects of mutations associated with hypertrophic cardiomyopathy and dilated cardiomyopathy, the native troponin complex in skinned trabecular fib...

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Detalles Bibliográficos
Autores principales: Groen, Marcel, López-Dávila, Alfredo Jesus, Zittrich, Stefan, Pfitzer, Gabriele, Stehle, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283609/
https://www.ncbi.nlm.nih.gov/pubmed/32581830
http://dx.doi.org/10.3389/fphys.2020.00516

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283609/
https://www.ncbi.nlm.nih.gov/pubmed/32581830
http://dx.doi.org/10.3389/fphys.2020.00516

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