Metformin Enhances Antidepressant/Antipsychotic Combination Therapy of Schizophrenia With Comorbid Depression in a Murine Model

Comorbid depressive disorders confound the diagnosis and therapy of schizophrenia. Using a murine model incorporating both MK801 and chronic unpredictable mild stress exposures, we successfully replicated both psychosis and depression. Ex vivo patch clamp recordings and in vivo calcium imaging demon...

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Detalles Bibliográficos
Autores principales: Zhou, Chunhua, Kong, Dezhi, Xue, Rong, Chen, Min, Li, Gongying, Xu, Yong, Liu, Sha, Tian, Hongjun, Zhuo, Chuanjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283619/
https://www.ncbi.nlm.nih.gov/pubmed/32581680
http://dx.doi.org/10.3389/fnins.2020.00517

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283619/
https://www.ncbi.nlm.nih.gov/pubmed/32581680
http://dx.doi.org/10.3389/fnins.2020.00517

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