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Phosphodiesterase 9A Inhibition Facilitates Corticostriatal Transmission in Wild-Type and Transgenic Rats That Model Huntington’s Disease

Huntington’s disease (HD) results from abnormal expansion in CAG trinucleotide repeats within the HD gene, a mutation which leads to degeneration of striatal medium-sized spiny neurons (MSNs), deficits in corticostriatal transmission, and loss of motor control. Recent studies also indicate that meta...

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Detalles Bibliográficos
Autores principales:	Chakroborty, Shreaya, Manfredsson, Fredric P., Dec, Alexander M., Campbell, Peter W., Stutzmann, Grace E., Beaumont, Vahri, West, Anthony R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283904/ https://www.ncbi.nlm.nih.gov/pubmed/32581668 http://dx.doi.org/10.3389/fnins.2020.00466

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