Phosphodiesterase 9A Inhibition Facilitates Corticostriatal Transmission in Wild-Type and Transgenic Rats That Model Huntington’s Disease

Huntington’s disease (HD) results from abnormal expansion in CAG trinucleotide repeats within the HD gene, a mutation which leads to degeneration of striatal medium-sized spiny neurons (MSNs), deficits in corticostriatal transmission, and loss of motor control. Recent studies also indicate that meta...

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Detalles Bibliográficos
Autores principales: Chakroborty, Shreaya, Manfredsson, Fredric P., Dec, Alexander M., Campbell, Peter W., Stutzmann, Grace E., Beaumont, Vahri, West, Anthony R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283904/
https://www.ncbi.nlm.nih.gov/pubmed/32581668
http://dx.doi.org/10.3389/fnins.2020.00466

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283904/
https://www.ncbi.nlm.nih.gov/pubmed/32581668
http://dx.doi.org/10.3389/fnins.2020.00466

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