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CD47 decline in pancreatic islet cells promotes macrophage-mediated phagocytosis in type I diabetes

BACKGROUND: Type I diabetes (T1D) is characterized by insulin loss caused by inflammatory cells that excessively infiltrate and destroy the pancreas, resulting in dysregulation of tissue homeostasis, mechanobiological properties, and the immune response. The streptozotocin (STZ)-induced mouse model...

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Detalles Bibliográficos
Autores principales: Zhang, Jing, Tan, Su-Bee, Guo, Zhi-Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284019/
https://www.ncbi.nlm.nih.gov/pubmed/32547698
http://dx.doi.org/10.4239/wjd.v11.i6.239