Ocular Tolerability and Immune Response to Corneal Intrastromal AAV-IDUA Gene Therapy in New Zealand White Rabbits

The chronic ocular toxicity, tolerability, and inflammation following corneal intrastromal injection of saline or escalating doses of an adeno-associated virus (AAV) containing a codon-optimized α-l-iduronidase (AAV-opt-IDUA) expression cassette were evaluated in New Zealand White rabbits. Corneal o...

Descripción completa

Detalles Bibliográficos
Autores principales: Song, Liujiang, Bower, Jacquelyn J., Llanga, Telmo, Salmon, Jacklyn H., Hirsch, Matthew L., Gilger, Brian C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284066/
https://www.ncbi.nlm.nih.gov/pubmed/32542182
http://dx.doi.org/10.1016/j.omtm.2020.05.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284066/
https://www.ncbi.nlm.nih.gov/pubmed/32542182
http://dx.doi.org/10.1016/j.omtm.2020.05.014

Ejemplares similares