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Ocular Tolerability and Immune Response to Corneal Intrastromal AAV-IDUA Gene Therapy in New Zealand White Rabbits

The chronic ocular toxicity, tolerability, and inflammation following corneal intrastromal injection of saline or escalating doses of an adeno-associated virus (AAV) containing a codon-optimized α-l-iduronidase (AAV-opt-IDUA) expression cassette were evaluated in New Zealand White rabbits. Corneal o...

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Detalles Bibliográficos
Autores principales:	Song, Liujiang, Bower, Jacquelyn J., Llanga, Telmo, Salmon, Jacklyn H., Hirsch, Matthew L., Gilger, Brian C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284066/ https://www.ncbi.nlm.nih.gov/pubmed/32542182 http://dx.doi.org/10.1016/j.omtm.2020.05.014

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