Stepwise Glucoheptoamidation of Poly(Amidoamine) Dendrimer G3 to Tune Physicochemical Properties of the Potential Drug Carrier: In Vitro Tests for Cytisine Conjugates

Third-generation poly(amidoamine) dendrimer (PAMAM) was modified by stepwise primary amine group amidation with d-glucoheptono-1,4-lactone. The physicochemical properties of the conjugates—size, ζ potential in lysosomal pH 5 and in neutral aqueous solutions, as well as intramolecular dynamics by dif...

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Detalles Bibliográficos
Autores principales: Czerniecka-Kubicka, Anna, Tutka, Piotr, Pyda, Marek, Walczak, Małgorzata, Uram, Łukasz, Misiorek, Maria, Chmiel, Ewelina, Wołowiec, Stanisław
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284344/
https://www.ncbi.nlm.nih.gov/pubmed/32456066
http://dx.doi.org/10.3390/pharmaceutics12050473

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284344/
https://www.ncbi.nlm.nih.gov/pubmed/32456066
http://dx.doi.org/10.3390/pharmaceutics12050473

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