Retina-Targeted Delivery of 17β-Estradiol by the Topically Applied DHED Prodrug

The purpose of this study was to explore retina-targeted delivery of 17β-estradiol (E2), a powerful neuroprotectant, by its bioprecursor prodrug 10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) administered as eye drops in animal models. Compared to the parent hormone, DHED displayed increased transcorn...

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Detalles Bibliográficos
Autores principales: Prokai-Tatrai, Katalin, Nguyen, Vien, De La Cruz, Daniel L., Guerra, Rebecca, Zaman, Khadiza, Rahlouni, Fatima, Prokai, Laszlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284430/
https://www.ncbi.nlm.nih.gov/pubmed/32429388
http://dx.doi.org/10.3390/pharmaceutics12050456

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284430/
https://www.ncbi.nlm.nih.gov/pubmed/32429388
http://dx.doi.org/10.3390/pharmaceutics12050456

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