Towards a Quantitative Mechanistic Understanding of Localized Pulmonary Tissue Retention—A Combined In Vivo/In Silico Approach Based on Four Model Drugs

Increasing affinity to lung tissue is an important strategy to achieve pulmonary retention and to prolong the duration of effect in the lung. As the lung is a very heterogeneous organ, differences in structure and blood flow may influence local pulmonary disposition. Here, a novel lung preparation t...

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Detalles Bibliográficos
Autores principales: Himstedt, Anneke, Braun, Clemens, Wicha, Sebastian Georg, Borghardt, Jens Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284631/
https://www.ncbi.nlm.nih.gov/pubmed/32365674
http://dx.doi.org/10.3390/pharmaceutics12050408

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284631/
https://www.ncbi.nlm.nih.gov/pubmed/32365674
http://dx.doi.org/10.3390/pharmaceutics12050408

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