Direct, Competitive Comparison of Linear, Monocyclic, and Bicyclic Libraries Using mRNA Display

[Image: see text] Peptide macrocyclization is typically associated with the development of higher affinity and more protease stable protein ligands, and, as such, is an important tool in peptide drug discovery. Yet, within the context of a diverse library, does cyclization give inherent advantages o...

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Detalles Bibliográficos
Autores principales: Hacker, David E., Abrigo, Nicolas A., Hoinka, Jan, Richardson, Stacie L., Przytycka, Teresa M., Hartman, Matthew C. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284801/
https://www.ncbi.nlm.nih.gov/pubmed/32418423
http://dx.doi.org/10.1021/acscombsci.0c00016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284801/
https://www.ncbi.nlm.nih.gov/pubmed/32418423
http://dx.doi.org/10.1021/acscombsci.0c00016

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