Cargando…

Bacteriophage-Derived Endolysins Applied as Potent Biocontrol Agents to Enhance Food Safety

Endolysins, bacteriophage-encoded enzymes, have emerged as antibacterial agents that can be actively applied in food processing systems as food preservatives to control pathogens and ultimately enhance food safety. Endolysins break down bacterial peptidoglycan structures at the terminal step of the...

Descripción completa

Detalles Bibliográficos
Autor principal: Chang, Yoonjee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285104/
https://www.ncbi.nlm.nih.gov/pubmed/32413991
http://dx.doi.org/10.3390/microorganisms8050724
_version_ 1783544621945585664
author Chang, Yoonjee
author_facet Chang, Yoonjee
author_sort Chang, Yoonjee
collection PubMed
description Endolysins, bacteriophage-encoded enzymes, have emerged as antibacterial agents that can be actively applied in food processing systems as food preservatives to control pathogens and ultimately enhance food safety. Endolysins break down bacterial peptidoglycan structures at the terminal step of the phage reproduction cycle to enable phage progeny release. In particular, endolysin treatment is a novel strategy for controlling antibiotic-resistant bacteria, which are a severe and increasingly frequent problem in the food industry. In addition, endolysins can eliminate biofilms on the surfaces of utensils. Furthermore, the cell wall-binding domain of endolysins can be used as a tool for rapidly detecting pathogens. Research to extend the use of endolysins toward Gram-negative bacteria is now being extensively conducted. This review summarizes the trends in endolysin research to date and discusses the future applications of these enzymes as novel food preservation tools in the field of food safety.
format Online
Article
Text
id pubmed-7285104
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-72851042020-06-18 Bacteriophage-Derived Endolysins Applied as Potent Biocontrol Agents to Enhance Food Safety Chang, Yoonjee Microorganisms Review Endolysins, bacteriophage-encoded enzymes, have emerged as antibacterial agents that can be actively applied in food processing systems as food preservatives to control pathogens and ultimately enhance food safety. Endolysins break down bacterial peptidoglycan structures at the terminal step of the phage reproduction cycle to enable phage progeny release. In particular, endolysin treatment is a novel strategy for controlling antibiotic-resistant bacteria, which are a severe and increasingly frequent problem in the food industry. In addition, endolysins can eliminate biofilms on the surfaces of utensils. Furthermore, the cell wall-binding domain of endolysins can be used as a tool for rapidly detecting pathogens. Research to extend the use of endolysins toward Gram-negative bacteria is now being extensively conducted. This review summarizes the trends in endolysin research to date and discusses the future applications of these enzymes as novel food preservation tools in the field of food safety. MDPI 2020-05-13 /pmc/articles/PMC7285104/ /pubmed/32413991 http://dx.doi.org/10.3390/microorganisms8050724 Text en © 2020 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chang, Yoonjee
Bacteriophage-Derived Endolysins Applied as Potent Biocontrol Agents to Enhance Food Safety
title Bacteriophage-Derived Endolysins Applied as Potent Biocontrol Agents to Enhance Food Safety
title_full Bacteriophage-Derived Endolysins Applied as Potent Biocontrol Agents to Enhance Food Safety
title_fullStr Bacteriophage-Derived Endolysins Applied as Potent Biocontrol Agents to Enhance Food Safety
title_full_unstemmed Bacteriophage-Derived Endolysins Applied as Potent Biocontrol Agents to Enhance Food Safety
title_short Bacteriophage-Derived Endolysins Applied as Potent Biocontrol Agents to Enhance Food Safety
title_sort bacteriophage-derived endolysins applied as potent biocontrol agents to enhance food safety
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285104/
https://www.ncbi.nlm.nih.gov/pubmed/32413991
http://dx.doi.org/10.3390/microorganisms8050724
work_keys_str_mv AT changyoonjee bacteriophagederivedendolysinsappliedaspotentbiocontrolagentstoenhancefoodsafety