Regulators of G-protein signaling, RGS2 and RGS4, inhibit protease-activated receptor 4-mediated signaling by forming a complex with the receptor and Gα in live cells

BACKGROUND: Protease-activated receptor 4 (PAR4) is a seven transmembrane G-protein coupled receptor (GPCR) activated by endogenous proteases, such as thrombin. PAR4 is involved in various pathophysiologies including cancer, inflammation, pain, and thrombosis. Although regulators of G-protein signal...

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Detalles Bibliográficos
Autores principales: Kim, Yukeyoung, Ghil, Sungho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285472/
https://www.ncbi.nlm.nih.gov/pubmed/32517689
http://dx.doi.org/10.1186/s12964-020-00552-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285472/
https://www.ncbi.nlm.nih.gov/pubmed/32517689
http://dx.doi.org/10.1186/s12964-020-00552-7

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