Antibody targeting tumor-derived soluble NKG2D ligand sMIC reprograms NK cell homeostatic survival and function and enhances melanoma response to PDL1 blockade therapy

BACKGROUND: Melanoma patients who have detectable serum soluble NKG2D ligands either at the baseline or post-treatment of PD1/PDL1 blockade exhibit poor overall survival. Among families of soluble human NKG2D ligands, the soluble human MHC I chain-related molecule (sMIC) was found to be elevated in...

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Detalles Bibliográficos
Autores principales: Basher, Fahmin, Dhar, Payal, Wang, Xin, Wainwright, Derek A., Zhang, Bin, Sosman, Jeffrey, Ji, Zhe, Wu, Jennifer D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285527/
https://www.ncbi.nlm.nih.gov/pubmed/32517713
http://dx.doi.org/10.1186/s13045-020-00896-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285527/
https://www.ncbi.nlm.nih.gov/pubmed/32517713
http://dx.doi.org/10.1186/s13045-020-00896-0

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