TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes

Gastrointestinal symptoms and fecal shedding of SARS-CoV-2 RNA are frequently observed in COVID-19 patients. However, it is unclear whether SARS-CoV-2 replicates in the human intestine and contributes to possible fecal-oral transmission. Here, we report productive infection of SARS-CoV-2 in ACE2(+)...

Descripción completa

Detalles Bibliográficos
Autores principales: Zang, Ruochen, Gomez Castro, Maria Florencia, McCune, Broc T., Zeng, Qiru, Rothlauf, Paul W., Sonnek, Naomi M., Liu, Zhuoming, Brulois, Kevin F., Wang, Xin, Greenberg, Harry B., Diamond, Michael S., Ciorba, Matthew A., Whelan, Sean P. J., Ding, Siyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285829/
https://www.ncbi.nlm.nih.gov/pubmed/32404436
http://dx.doi.org/10.1126/sciimmunol.abc3582

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285829/
https://www.ncbi.nlm.nih.gov/pubmed/32404436
http://dx.doi.org/10.1126/sciimmunol.abc3582

Ejemplares similares