Optimization of the rat digit abduction score (DAS) assay: Evaluation of botulinum neurotoxin activity in the gastrocnemius lateralis, peronei, and extensor digitorum longus

The mouse digit abduction score (DAS) assay is commonly used to measure muscle flaccidity-inducing effects of botulinum neurotoxin (BoNT) in vivo. Adapting the assay to rats has been challenging, as injection of onabotulinumtoxinA (onaBoNT-A) into the gastrocnemius muscle, as performed in mice, or i...

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Detalles Bibliográficos
Autores principales: Cornet, Sylvie, Périer, Cindy, Kalinichev, Mikhail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285904/
https://www.ncbi.nlm.nih.gov/pubmed/32550584
http://dx.doi.org/10.1016/j.toxcx.2020.100029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285904/
https://www.ncbi.nlm.nih.gov/pubmed/32550584
http://dx.doi.org/10.1016/j.toxcx.2020.100029

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