AMPK decreases ERK1/2 activity and cancer cell sensitivity to nutrition deprivation by mediating a positive feedback loop involving eEF2K

Nutrition deprivation (ND) is a common feature of the tumor microenvironment. Tumor cells, therefore, frequently develop resistance mechanisms against ND. One of these mechanisms is the activation of the AMP-activated protein kinase (AMPK), which promotes cell survival under ND. AMPK activation prom...

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Detalles Bibliográficos
Autores principales: Tong, Shujuan, Zhou, Tao, Meng, Yufen, Xu, Dongqin, Chen, Jianping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286132/
https://www.ncbi.nlm.nih.gov/pubmed/32565934
http://dx.doi.org/10.3892/ol.2020.11554

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286132/
https://www.ncbi.nlm.nih.gov/pubmed/32565934
http://dx.doi.org/10.3892/ol.2020.11554

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