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Serologic Markers of Previous Malaria Exposure and Functional Antibodies Inhibiting Parasite Growth Are Associated With Parasite Kinetics Following a Plasmodium falciparum Controlled Human Infection

BACKGROUND: We assessed the impact of exposure to Plasmodium falciparum on parasite kinetics, clinical symptoms, and functional immunity after controlled human malaria infection (CHMI) in 2 cohorts with different levels of previous malarial exposure. METHODS: Nine adult males with high (sero-high) a...

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Detalles Bibliográficos
Autores principales: Achan, Jane, Reuling, Isaie J, Yap, Xi Zen, Dabira, Edgard, Ahmad, Abdullahi, Cox, Momodou, Nwakanma, Davis, Tetteh, Kevin, Wu, Lindsey, Bastiaens, Guido J H, Abebe, Yonas, Manoj, Anita, Kaur, Harparkash, Miura, Kazutoyo, Long, Carole, Billingsley, Peter F, Sim, B Kim Lee, Hoffman, Stephen L, Drakeley, Chris, Bousema, Teun, D’Alessandro, Umberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286377/
https://www.ncbi.nlm.nih.gov/pubmed/31402382
http://dx.doi.org/10.1093/cid/ciz740