Pharmacological inhibition of carnitine palmitoyl transferase 1 inhibits and reverses experimental autoimmune encephalitis in rodents

Multiple sclerosis (MS) is a neurodegenerative disease characterized by demyelination and inflammation. Dysregulated lipid metabolism and mitochondrial dysfunction are hypothesized to play a key role in MS. Carnitine Palmitoyl Transferase 1 (CPT1) is a rate-limiting enzyme for beta-oxidation of fatt...

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Detalles Bibliográficos
Autores principales: Mørkholt, Anne Skøttrup, Oklinski, Michal Krystian, Larsen, Agnete, Bockermann, Robert, Issazadeh-Navikas, Shohreh, Nieland, Jette Goller Kloth, Kwon, Tae-Hwan, Corthals, Angelique, Nielsen, Søren, Nieland, John Dirk Vestergaard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286491/
https://www.ncbi.nlm.nih.gov/pubmed/32520953
http://dx.doi.org/10.1371/journal.pone.0234493

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286491/
https://www.ncbi.nlm.nih.gov/pubmed/32520953
http://dx.doi.org/10.1371/journal.pone.0234493

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