Inhibition of the translesion synthesis polymerase REV1 exploits replication gaps as a cancer vulnerability

The replication stress response, which serves as an anticancer barrier, is activated not only by DNA damage and replication obstacles but also oncogenes, thus obscuring how cancer evolves. Here, we identify that oncogene expression, similar to other replication stress–inducing agents, induces single...

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Detalles Bibliográficos
Autores principales: Nayak, Sumeet, Calvo, Jennifer A., Cong, Ke, Peng, Min, Berthiaume, Emily, Jackson, Jessica, Zaino, Angela M., Vindigni, Alessandro, Hadden, M. Kyle, Cantor, Sharon B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286678/
https://www.ncbi.nlm.nih.gov/pubmed/32577513
http://dx.doi.org/10.1126/sciadv.aaz7808

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286678/
https://www.ncbi.nlm.nih.gov/pubmed/32577513
http://dx.doi.org/10.1126/sciadv.aaz7808

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