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Accelerated evolution of a minimal 63–amino acid dual transcription factor

Transcription factors control gene expression in all life. This raises the question of what is the smallest protein that can support such activity. In nature, Cro from bacteriophage λ is one of the smallest known repressors (66 amino acids), and activators are typically much larger (e.g., λ cI, 237...

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Detalles Bibliográficos
Autores principales: Brödel, Andreas K., Rodrigues, Rui, Jaramillo, Alfonso, Isalan, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286687/
https://www.ncbi.nlm.nih.gov/pubmed/32577520
http://dx.doi.org/10.1126/sciadv.aba2728