Biliary damage and liver fibrosis are ameliorated in a novel mouse model lacking l-histidine decarboxylase/histamine signaling

Primary sclerosing cholangitis (PSC) is characterized by biliary damage and fibrosis. Multidrug resistance-2 gene knockout (Mdr2(−/−)) mice and PSC patients have increased histamine (HA) levels (synthesized by l-histidine decarboxylase, HDC) and HA receptor (HR) expression. Cholestatic HDC(−/−) mice...

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Detalles Bibliográficos
Autores principales: Kennedy, Lindsey, Meadows, Vik, Demieville, Jennifer, Hargrove, Laura, Virani, Shohaib, Glaser, Shannon, Zhou, Tianhao, Rinehart, Evan, Jaeger, Victoria, Kyritsi, Konstantina, Pham, Linh, Alpini, Gianfranco, Francis, Heather
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286781/
https://www.ncbi.nlm.nih.gov/pubmed/32054995
http://dx.doi.org/10.1038/s41374-020-0405-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286781/
https://www.ncbi.nlm.nih.gov/pubmed/32054995
http://dx.doi.org/10.1038/s41374-020-0405-8

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