Cargando…

Biliary damage and liver fibrosis are ameliorated in a novel mouse model lacking l-histidine decarboxylase/histamine signaling

Primary sclerosing cholangitis (PSC) is characterized by biliary damage and fibrosis. Multidrug resistance-2 gene knockout (Mdr2(−/−)) mice and PSC patients have increased histamine (HA) levels (synthesized by l-histidine decarboxylase, HDC) and HA receptor (HR) expression. Cholestatic HDC(−/−) mice...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kennedy, Lindsey, Meadows, Vik, Demieville, Jennifer, Hargrove, Laura, Virani, Shohaib, Glaser, Shannon, Zhou, Tianhao, Rinehart, Evan, Jaeger, Victoria, Kyritsi, Konstantina, Pham, Linh, Alpini, Gianfranco, Francis, Heather
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286781/ https://www.ncbi.nlm.nih.gov/pubmed/32054995 http://dx.doi.org/10.1038/s41374-020-0405-8

Ejemplares similares

Histamine and histidine decarboxylase: Immunomodulatory functions and regulatory mechanisms
por: Moriguchi, Takashi, et al.
Publicado: (2020)

Mast cells selectively target large cholangiocytes during biliary injury via H2HR‐mediated cAMP/pERK1/2 signaling
por: Zhou, Tianhao, et al.
Publicado: (2022)

Knockout of microRNA-21 reduces biliary hyperplasia and liver fibrosis in cholestatic bile duct ligated mice
por: Kennedy, Lindsey, et al.
Publicado: (2016)

The Effects of Taurocholic Acid on Biliary Damage and Liver Fibrosis Are Mediated by Calcitonin-Gene-Related Peptide Signaling
por: Mancinelli, Romina, et al.
Publicado: (2022)

Associations of Polymorphisms in Histidine Decarboxylase, Histamine N-Methyltransferase and Histamine Receptor H(3) Genes with Breast Cancer
por: He, Gong-Hao, et al.
Publicado: (2014)

Enhanced histamine production through the induction of histidine decarboxylase expression by phorbol ester in Jurkat cells
por: NAGASHIMA, YUSUKE, et al.
Publicado: (2012)

Biliary Epithelial Senescence in Liver Disease: There Will Be SASP
por: Meadows, Vik, et al.
Publicado: (2021)

Knockout of secretin receptor reduces biliary damage and liver fibrosis in Mdr2(−/−) mice by diminishing senescence of cholangiocytes
por: Zhou, Tianhao, et al.
Publicado: (2018)

Comprehensive Review of Molecular Mechanisms during Cholestatic Liver Injury and Cholangiocarcinoma
por: Virani, Shohaib, et al.
Publicado: (2018)

Cyclic AMP Signaling in Biliary Proliferation: A Possible Target for Cholangiocarcinoma Treatment?
por: Baiocchi, Leonardo, et al.
Publicado: (2021)

The regulation of histidine decarboxylase gene expression.
por: Höcker, M., et al.
Publicado: (1996)

Knockout of secretin ameliorates biliary and liver phenotypes during alcohol-induced hepatotoxicity
por: Kyritsi, Konstantina, et al.
Publicado: (2023)

Inhibitory Activity of the Flower Buds of Lonicera japonica Thunb. against Histamine Production and l-Histidine Decarboxylase in Human Keratinocytes
por: Inami, Yoshihiro, et al.
Publicado: (2014)

Mechanisms of Biliary Damage
por: Yang, Fuquan, et al.
Publicado: (2010)

Molecular biology of histidine decarboxylase and prostaglandin receptors
por: ICHIKAWA, Atsushi, et al.
Publicado: (2010)

Expression of Histidine Decarboxylase and Its Roles in Inflammation
por: Hirasawa, Noriyasu
Publicado: (2019)

FGF1 Signaling Modulates Biliary Injury and Liver Fibrosis in the Mdr2(−/−) Mouse Model of Primary Sclerosing Cholangitis
por: O’Brien, April, et al.
Publicado: (2022)

Dual Role of Bile Acids on the Biliary Epithelium: Friend or Foe?
por: Baiocchi, Leonardo, et al.
Publicado: (2019)

Ursodeoxycholate inhibits mast cell activation and reverses biliary injury and fibrosis in Mdr2(−/−) mice and human primary sclerosing cholangitis
por: Meng, Fanyin, et al.
Publicado: (2018)

Role of histidine decarboxylase gene in the pathogenesis of Tourette syndrome
por: Xu, Lulu, et al.
Publicado: (2022)

Feedback Signaling between Cholangiopathies, Ductular Reaction, and Non-Alcoholic Fatty Liver Disease
por: Zhou, Tianhao, et al.
Publicado: (2021)

Lipopolysaccharide-induced expansion of histidine decarboxylase-expressing Ly6G(+) myeloid cells identified by exploiting histidine decarboxylase BAC-GFP transgenic mice
por: Takai, Jun, et al.
Publicado: (2019)

Knockdown of vimentin reduces mesenchymal phenotype of cholangiocytes in the Mdr2(−/−) mouse model of primary sclerosing cholangitis (PSC)
por: Zhou, Tianhao, et al.
Publicado: (2019)

Control of histidine decarboxylase gene expression in enterochromaffin-like cells.
por: Dimaline, R., et al.
Publicado: (1998)

Histidine Decarboxylase Deficiency Prevents Autoimmune Diabetes in NOD Mice
por: Alkan, Manal, et al.
Publicado: (2015)

Emerging Therapeutic Strategies in The Fight Against Primary Biliary Cholangitis
por: Medford, Abigail, et al.
Publicado: (2023)

Bile Acid Receptor Therapeutics Effects on Chronic Liver Diseases
por: Meadows, Vik, et al.
Publicado: (2020)

Bile acid signaling and biliary functions
por: Jones, Hannah, et al.
Publicado: (2015)

Role of Non-Coding RNAs in the Progression of Liver Cancer: Evidence from Experimental Models
por: O’Brien, April, et al.
Publicado: (2019)

Impact of Aging on Liver Cells and Liver Disease: Focus on the Biliary and Vascular Compartments
por: Baiocchi, Leonardo, et al.
Publicado: (2021)

Knockout of α-calcitonin gene-related peptide attenuates cholestatic liver injury by differentially regulating cellular senescence of hepatic stellate cells and cholangiocytes
por: Wan, Ying, et al.
Publicado: (2019)

Pathophysiological Roles of Ductular Reaction in Liver Inflammation and Hepatic Fibrogenesis
por: Sato, Keisaku, et al.
Publicado: (2022)

Anti-Allergic Effects of Myrciaria dubia (Camu-Camu) Fruit Extract by Inhibiting Histamine H1 and H4 Receptors and Histidine Decarboxylase in RBL-2H3 Cells
por: Do, Nhung Quynh, et al.
Publicado: (2021)

FLI1 Regulates Histamine Decarboxylase Expression to Control Inflammation Signaling and Leukemia Progression
por: Hu, Jifen, et al.
Publicado: (2023)

Molecular Mechanisms Linking Risk Factors to Cholangiocarcinoma Development
por: Ceci, Ludovica, et al.
Publicado: (2022)

High-throughput DNA sequencing to survey bacterial histidine and tyrosine decarboxylases in raw milk cheeses
por: O’Sullivan, Daniel J., et al.
Publicado: (2015)

Hypothalamic L-Histidine Decarboxylase Is Up-Regulated During Chronic REM Sleep Deprivation of Rats
por: Hoffman, Gloria E., et al.
Publicado: (2016)

Actinobacterial Coproheme Decarboxylases Use Histidine as a Distal Base to Promote Compound I Formation
por: Michlits, Hanna, et al.
Publicado: (2020)

Prolonged Administration of Melatonin Ameliorates Liver Phenotypes in Cholestatic Murine Model
por: Ceci, Ludovica, et al.
Publicado: (2022)

Defective Angiogenesis in the Inflammatory Granulation Tissue in Histidine Decarboxylase–deficient Mice but not in Mast Cell–deficient Mice
por: Ghosh, Ajoy Kumar, et al.
Publicado: (2002)

Cannot write session to /tmp/vufind_sessions/sess_ttk4bdv9i5rbb6kt4kkb2anlig