Wolfram syndrome 1 gene regulates pathways maintaining beta cell health and survival

Wolfram Syndrome 1 (WFS1) protein is an endoplasmic reticulum (ER) factor whose deficiency results in juvenile-onset diabetes secondary to cellular dysfunction and apoptosis. The mechanisms guiding β-cell outcomes secondary to WFS1 function, however, remain unclear. Here, we show that WFS1 preserves...

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Detalles Bibliográficos
Autores principales: Abreu, Damien, Asada, Rie, Revilla, John M. P., Lavagnino, Zeno, Kries, Kelly, Piston, David W., Urano, Fumihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286786/
https://www.ncbi.nlm.nih.gov/pubmed/32060407
http://dx.doi.org/10.1038/s41374-020-0408-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286786/
https://www.ncbi.nlm.nih.gov/pubmed/32060407
http://dx.doi.org/10.1038/s41374-020-0408-5

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