FBP1 loss disrupts liver metabolism and promotes tumourigenesis through a hepatic stellate cell senescence secretome

Crosstalk between deregulated hepatocyte metabolism and cells within the tumour microenvironment, and consequent effects on liver tumourigenesis, are incompletely understood. We show here that hepatocyte-specific loss of the gluconeogenic enzyme fructose 1,6-bisphosphatase 1 (FBP1) disrupts liver me...

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Detalles Bibliográficos
Autores principales: Li, Fuming, Huangyang, Peiwei, Burrows, Michelle, Guo, Kathy, Riscal, Romain, Godfrey, Jason, Lee, Kyoung Eun, Lin, Nan, Lee, Pearl, Blair, Ian A., Keith, Brian, Li, Bo, Simon, M. Celeste
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286794/
https://www.ncbi.nlm.nih.gov/pubmed/32367049
http://dx.doi.org/10.1038/s41556-020-0511-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286794/
https://www.ncbi.nlm.nih.gov/pubmed/32367049
http://dx.doi.org/10.1038/s41556-020-0511-2

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