Cargando…
Therapeutic targeting of p300/CBP HAT domain for the treatment of NUT midline carcinoma
Nuclear protein of the testis (NUT) midline carcinoma (NMC), is a rare and highly aggressive form of undifferentiated squamous cell carcinoma. NMC is molecularly characterized by chromosomal rearrangement of the NUT gene to another gene, most commonly the bromodomain and extraterminal domain (BET) g...
Autores principales: | Zhang, Xin, Zegar, Tim, Lucas, Anais, Morrison-Smith, Chevaun, Knox, Tatiana, French, Christopher A., Knapp, Stefan, Müller, Susanne, Siveke, Jens T. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286816/ https://www.ncbi.nlm.nih.gov/pubmed/32366905 http://dx.doi.org/10.1038/s41388-020-1301-9 |
Ejemplares similares
-
HBZ inhibits the HAT activity of the cellular coactivators p300 and CBP
por: Wright, Diana, et al.
Publicado: (2011) -
Inhibition of histone acetyltransferase (HAT) activity by HBZ extends beyond the p300/CBP HAT family
por: Wright, Diana G, et al.
Publicado: (2014) -
Selective inhibition of CBP/p300 HAT by A-485 results in suppression of lipogenesis and hepatic gluconeogenesis
por: Zhou, Feiye, et al.
Publicado: (2020) -
CBP/p300 HAT maintains the gene network critical for β cell identity and functional maturity
por: Zhang, Linlin, et al.
Publicado: (2021) -
The ZZ domain of p300 mediates specificity of the adjacent HAT domain for histone H3
por: Zhang, Yi, et al.
Publicado: (2018)