SIRT7 activates p53 by enhancing PCAF-mediated MDM2 degradation to arrest the cell cycle

Sirtuin 7 (SIRT7), an NAD(+)-dependent deacetylase, plays vital roles in energy sensing, but the underlying mechanisms of action remain less clear. Here, we report that SIRT7 is required for p53-dependent cell-cycle arrest during glucose deprivation. We show that SIRT7 directly interacts with p300/C...

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Detalles Bibliográficos
Autores principales: Lu, Ya-Fei, Xu, Xiao-Peng, Lu, Xiao-Peng, Zhu, Qian, Liu, Ge, Bao, Yan-Tao, Wen, He, Li, Ying-Lu, Gu, Wei, Zhu, Wei-Guo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286819/
https://www.ncbi.nlm.nih.gov/pubmed/32404984
http://dx.doi.org/10.1038/s41388-020-1305-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286819/
https://www.ncbi.nlm.nih.gov/pubmed/32404984
http://dx.doi.org/10.1038/s41388-020-1305-5

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