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SIRT7 activates p53 by enhancing PCAF-mediated MDM2 degradation to arrest the cell cycle
Sirtuin 7 (SIRT7), an NAD(+)-dependent deacetylase, plays vital roles in energy sensing, but the underlying mechanisms of action remain less clear. Here, we report that SIRT7 is required for p53-dependent cell-cycle arrest during glucose deprivation. We show that SIRT7 directly interacts with p300/C...
Autores principales: | Lu, Ya-Fei, Xu, Xiao-Peng, Lu, Xiao-Peng, Zhu, Qian, Liu, Ge, Bao, Yan-Tao, Wen, He, Li, Ying-Lu, Gu, Wei, Zhu, Wei-Guo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286819/ https://www.ncbi.nlm.nih.gov/pubmed/32404984 http://dx.doi.org/10.1038/s41388-020-1305-5 |
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