Cargando…

Naringin alleviates methotrexate-induced liver injury in male albino rats and enhances its antitumor efficacy in HepG2 cells

Methotrexate (MTX) is an efficient chemotherapeutic and immunosuppressant drug, but the hepatotoxicity of MTX limits its clinical use. Naringin (Nar) is a flavonoid derived from Citrus paradise, and has been shown to possess several pharmacological activities, including free-radical scavenging and a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Elsawy, Hany, Algefare, Abdulmohsen I., Alfwuaires, Manal, Khalil, Mahmoud, Elmenshawy, Omar M., Sedky, Azza, Abdel-Moneim, Ashraf M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2020
Materias:	Therapeutics & Molecular Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286878/ https://www.ncbi.nlm.nih.gov/pubmed/32458964 http://dx.doi.org/10.1042/BSR20193686

Ejemplares similares

Beneficial role of naringin against methotrexate-induced injury to rat testes: biochemical and ultrastructural analyses
por: Elsawy, Hany, et al.
Publicado: (2022)

Acacetin Inhibits Cell Proliferation and Induces Apoptosis in Human Hepatocellular Carcinoma Cell Lines
por: Alfwuaires, Manal, et al.
Publicado: (2022)

Ruscogenin Protects Against Deoxynivalenol-Induced Hepatic Injury by Inhibiting Oxidative Stress, Inflammation, and Apoptosis Through the Nrf2 Signaling Pathway: An In vitro Study
por: Elsawy, Hany, et al.
Publicado: (2022)

In vivo evaluation of the protective effects of arjunolic acid against lipopolysaccharide-induced septic myocardial injury
por: Elsawy, Hany, et al.
Publicado: (2022)

Antioxidant Potential of Parsley Leaf (Petroselinum crispum) Essential Oil on Hypothyroidism and Testicular Injury in Mice Intoxicated by Carbon Tetrachloride
por: Badr, Gehan M., et al.
Publicado: (2021)

Rutin ameliorates carbon tetrachloride (CCl(4))-induced hepatorenal toxicity and hypogonadism in male rats
por: Elsawy, Hany, et al.
Publicado: (2019)

Capric Acid Behaves Agonistic Effect on Calcitriol to Control Inflammatory Mediators in Colon Cancer Cells
por: Negm, Amr, et al.
Publicado: (2022)

Antidiabetic Wound Dressing Materials Based on Cellulosic Fabrics Loaded with Zinc Oxide Nanoparticles Synthesized by Solid-State Method
por: Elsawy, Hany, et al.
Publicado: (2022)

The effects of naringenin and naringin on the glucose uptake and AMPK phosphorylation in high glucose treated HepG2 cells
por: Dayarathne, Lakshi A., et al.
Publicado: (2021)

Combination therapy with PEG-IFN-α and 5-FU inhibits HepG2 tumour cell growth in nude mice by apoptosis of p53
por: Hagiwara, S, et al.
Publicado: (2007)

Inhibition of VEGF expression through blockade of Hif1α and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells
por: Carbajo-Pescador, S, et al.
Publicado: (2013)

Punicalagin Protects against the Development of Methotrexate-Induced Hepatotoxicity in Mice via Activating Nrf2 Signaling and Decreasing Oxidative Stress, Inflammation, and Cell Death
por: Al-khawalde, Alayn’ Al-marddyah A., et al.
Publicado: (2022)

Unraveling the in vitro antitumor activity of Vismia baccifera against HepG2: role of hydrogen peroxide
por: Trepiana, Jenifer, et al.
Publicado: (2018)

Renoprotective and Oxidative Stress-Modulating Effects of Taxifolin against Cadmium-Induced Nephrotoxicity in Mice
por: Algefare, Abdulmohsen I.
Publicado: (2022)

Antitumor effect and mechanism of an ellagic acid derivative on the HepG2 human hepatocellular carcinoma cell line
por: ZHANG, HUI, et al.
Publicado: (2014)

Methotrexate used in combination with aminolaevulinic acid for photodynamic killing of prostate cancer cells
por: Sinha, A K, et al.
Publicado: (2006)

Hepatoprotective effect of taxifolin on cyclophosphamide-induced oxidative stress, inflammation, and apoptosis in mice: Involvement of Nrf2/HO-1 signaling
por: Althunibat, Osama Y, et al.
Publicado: (2023)

γ-Glutamyl hydrolase modulation and folate influence chemosensitivity of cancer cells to 5-fluorouracil and methotrexate
por: Kim, S-E, et al.
Publicado: (2013)

Artificial cells eavesdropping on HepG2 cells
por: Westensee, Isabella Nymann, et al.
Publicado: (2023)

Cardioprotective Effect of Taxifolin against Isoproterenol-Induced Cardiac Injury through Decreasing Oxidative Stress, Inflammation, and Cell Death, and Activating Nrf2/HO-1 in Mice
por: Obeidat, Heba M., et al.
Publicado: (2022)

Synthesis and antitumor activity against HepG-2, PC-3, and HCT-116 cells of some naphthyridine and pyranopyridinecarbonitrile derivatives
por: Mohamed, S. F., et al.
Publicado: (2017)

Melatonin is a potential oncostatic agent to inhibit HepG2 cell proliferation through multiple pathways
por: Ammar, Omar A., et al.
Publicado: (2022)

Impact of gervital against histopathological, ultrastructural, and biochemical alterations caused by methotrexate or azathioprine in albino rat testis
por: Abdul-Hamid, Manal, et al.
Publicado: (2022)

Anti-tumor effect of volatile oil from Houttuynia cordata Thunb. on HepG2 cells and HepG2 tumor-bearing mice
por: Yang, Linsong, et al.
Publicado: (2019)

DNMT1/PKR double knockdowned HepG2 (HepG2-DP) cells have high hepatic function and differentiation ability
por: Tanaka-yachi, Rieko, et al.
Publicado: (2022)

NaHCO(3) enhances the antitumor activities of cytokine-induced killer cells against hepatocellular carcinoma HepG2 cells
por: Yuan, Ya Hong, et al.
Publicado: (2016)

Formononetin Ameliorates Renal Dysfunction, Oxidative Stress, Inflammation, and Apoptosis and Upregulates Nrf2/HO-1 Signaling in a Rat Model of Gentamicin-Induced Nephrotoxicity
por: Althunibat, Osama Y., et al.
Publicado: (2022)

COMPARATIVE THERAPEUTIC EVALUATION OF DIFFERENT TOPICALS AND NARROW BAND ULTRAVIOLET B THERAPY COMBINED WITH SYSTEMIC METHOTREXATE IN THE TREATMENT OF PALMOPLANTAR PSORIASIS
por: Gupta, Sunil K, et al.
Publicado: (2011)

Characterization of dengue virus entry into HepG2 cells
por: Suksanpaisan, Lukkana, et al.
Publicado: (2009)

Selectivity of biopolymer membranes using HepG2 cells
por: Lü, Dongyuan, et al.
Publicado: (2015)

Curcumin Effect on Copper Transport in HepG2 Cells
por: Berzina, Anita, et al.
Publicado: (2018)

Cholesterol-lowing effect of taurine in HepG2 cell
por: Guo, Junxia, et al.
Publicado: (2017)

Nevirapine induced mitochondrial dysfunction in HepG2 cells
por: Paemanee, Atchara, et al.
Publicado: (2017)

The Expectation and Reality of the HepG2 Core Metabolic Profile
por: Kiseleva, Olga I., et al.
Publicado: (2023)

Transforming Growth Factor-β2 protects the small intestine during methotrexate treatment in rats possibly by reducing stem cell cycling
por: van't Land, B, et al.
Publicado: (2002)

PD‐1 Pathway Inhibitors: Immuno‐Oncology Agents for Restoring Antitumor Immune Responses
por: Medina, Patrick J., et al.
Publicado: (2016)

Encapsulation of Lovastatin in Zein Nanoparticles Exhibits Enhanced Apoptotic Activity in HepG2 Cells
por: Alhakamy, Nabil A., et al.
Publicado: (2019)

The Genoprotective Role of Naringin
por: Szczepaniak, Oskar, et al.
Publicado: (2020)

TMEM2 inhibits hepatitis B virus infection in HepG2 and HepG2.2.15 cells by activating the JAK–STAT signaling pathway
por: Zhu, X, et al.
Publicado: (2016)

Spinosad Induces Antioxidative Response and Ultrastructure Changes in Males of Red Palm Weevil Rhynchophorus ferrugineus (Coleoptera: Dryophthoridae)
por: Abdelsalam, Salaheldin A., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_k82ohage0v1hnk3c119r7n4m83