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Distinct metabolic states of a cell guide alternate fates of mutational buffering through altered proteostasis
Metabolic changes alter the cellular milieu; can this also change intracellular protein folding? Since proteostasis can modulate mutational buffering, if change in metabolism has the ability to change protein folding, arguably, it should also alter mutational buffering. Here we find that altered cel...
Autores principales: | Verma, Kanika, Saxena, Kanika, Donaka, Rajashekar, Chaphalkar, Aseem, Rai, Manish Kumar, Shukla, Anurag, Zaidi, Zainab, Dandage, Rohan, Shanmugam, Dhanasekaran, Chakraborty, Kausik |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286901/ https://www.ncbi.nlm.nih.gov/pubmed/32522991 http://dx.doi.org/10.1038/s41467-020-16804-6 |
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